Platelet Transfusion for Trauma Resuscitation

Abstract Purpose of Review To review the role platelet transfusion in resuscitation for trauma, including normal function and alterations behavior following blood product ratios impact on function, assays, risks considerations storage, potential adjunct therapies synthetic platelets. Recent Findings Platelets are a critical component clot formation breakdown injury, addition to these hemostatic properties, have complex vascular homeostasis, inflammation, immune function. Evidence supports that platelets activated trauma with several upregulated functions, but under conditions severe injury shock found be impaired their behaviors. should transfused balanced red cells plasma during initial as this portends improved outcomes survival. Multiple coagulation assays can used goal-directed traumatic hemorrhage; however, each drawbacks terms ability measure While is supported by literature, carries its own such bacterial infection lung injury. Platelet supply also limited, resource-intensive storage requirements, making exploration longer-term options novel platelet-based therapeutics attractive. Future focus deeper understanding biology optimization maintain effects while improving availability pursued. Summary altered resuscitation. Severe impair which persist days trauma. Assays guide period well techniques extend shelf life important areas investigation.